Medications and addictive substances potentially inducing or attenuating sleep bruxism and/or awake bruxism

Bruxism is a repetitive jaw-muscle activity characterised by clenching or grinding of the teeth and/or by bracing or thrusting of the mandible. It can occur during sleep, indicated as sleep bruxism, or during wakefulness, indicated as awake bruxism. Exogenous risk indicators of sleep bruxism and/or awake bruxism are, among others, medications and addictive substances, whereas also several medications seem to have the potential to attenuate sleep bruxism and/or awake bruxism. The objective of this study was to present a narrative literature on medications and addictive substances potentially inducing or aggravating sleep bruxism and/or awake bruxism and on medications potentially attenuating sleep bruxism and/or awake bruxism. Literature reviews reporting evidence or indications for sleep bruxism and/or awake bruxism as an adverse effect of several (classes of) medications as well as some addictive substances and literature reviews on medications potentially attenuating sleep bruxism and/or awake bruxism were used as starting point and guidelines to describe the topics mentioned. Additionally, two literature searches were established on PubMed. Three types of bruxism were distinguished: sleep bruxism, awake bruxism and non-specified bruxism. Generally, there are insufficient evidence-based data to draw definite conclusions concerning medications and addictive substances inducing or aggravating sleep bruxism and/or awake bruxism as well as concerning medications attenuating sleep bruxism and/or awake bruxism. There are insufficient evidence-based data to draw definite conclusions concerning medications and addictive substances inducing or aggravating sleep bruxism and/or awake bruxism as well as concerning medications attenuating sleep bruxism and/or awake bruxism.Peer reviewe

Grey and white matter correlates of recent and remote autobiographical memory retrieval:Insights from the dementias

The capacity to remember self-referential past events relies on the integrity of a distributed neural network. Controversy exists, however, regarding the involvement of specific brain structures for the retrieval of recently experienced versus more distant events. Here, we explored how characteristic patterns of atrophy in neurodegenerative disorders differentially disrupt remote versus recent autobiographical memory. Eleven behavioural-variant frontotemporal dementia, 10 semantic dementia, 15 Alzheimer's disease patients and 14 healthy older Controls completed the Autobiographical Interview. All patient groups displayed significant remote memory impairments relative to Controls. Similarly, recent period retrieval was significantly compromised in behavioural-variant frontotemporal dementia and Alzheimer's disease, yet semantic dementia patients scored in line with Controls. Voxel-based morphometry and diffusion tensor imaging analyses, for all participants combined, were conducted to investigate grey and white matter correlates of remote and recent autobiographical memory retrieval. Neural correlates common to both recent and remote time periods were identified, including the hippocampus, medial prefrontal, and frontopolar cortices, and the forceps minor and left hippocampal portion of the cingulum bundle. Regions exclusively implicated in each time period were also identified. The integrity of the anterior temporal cortices was related to the retrieval of remote memories, whereas the posterior cingulate cortex emerged as a structure significantly associated with recent autobiographical memory retrieval. This study represents the first investigation of the grey and white matter correlates of remote and recent autobiographical memory retrieval in neurodegenerative disorders. Our findings demonstrate the importance of core brain structures, including the medial prefrontal cortex and hippocampus, irrespective of time period, and point towards the contribution of discrete regions in mediating successful retrieval of distant versus recently experienced events

Bruxism and psychotropic medications

This is an accepted manuscript of an article published by Wiley in Progress in Neurology and Psychiatry on 13/02/2020, available online: https://wchh.onlinelibrary.wiley.com/doi/10.1002/pnp.560 The accepted version of the publication may differ from the final published version.Mental Health Disorders including schizophrenia, bipolar and schizoaffective disorders are often treated using psychotropic medications with evidence that some of these medications such as antipsychotics could be associated with significant oral side-effects. In this comprehensive review, we examine the psychotropic medications mechanisms of action and their oral side-effects, with specific focus on psychotropic medications and bruxism as a major oral health complication with a negative impact on the quality of life of mental health sufferers, relevant to psychiatrists, dentists and general practitioners. Bruxism could be caused by the antipsychotics extrapyramidal side-effects through dopaminergic receptors. Bruxism as a side-effect of psychotropic medications could result in significant consequences to oral health such as tooth structure destruction and irreversible harm to the temporomandibular joint. The review findings could assist in understanding the aetiology of bruxism, establish appropriate management plan, while supporting psychiatrists and dentists to detect temporomandibular dysfunctions (TMD) such as bruxism

Lengua, comunicación e información

This book, which emerges from the presentations made in the Faculty of Information and Communication in 2017 during two academic meetings: the Colloquium Communication, language and information: reading and writing in academic key and the thematic table Multiple looks for multiple literacies, made in the II Research Days. The written versions of these works are available, which have allowed to start a dialogue about academic reading and writing from three perspectives: communication, information and language sciences. It is hoped that this text will contribute to the dialogue between disciplines not only with the aim of improving the understanding of the same object - writing practices and the processing and communication of information in academic fields - but also contribute to improving teaching, a primary goal of the University of the Republic

Lengua, comunicación e información

This book, which emerges from the presentations made in the Faculty of Information and Communication in 2017 during two academic meetings: the Colloquium Communication, language and information: reading and writing in academic key and the thematic table Multiple looks for multiple literacies, made in the II Research Days. The written versions of these works are available, which have allowed to start a dialogue about academic reading and writing from three perspectives: communication, information and language sciences. It is hoped that this text will contribute to the dialogue between disciplines not only with the aim of improving the understanding of the same object - writing practices and the processing and communication of information in academic fields - but also contribute to improving teaching, a primary goal of the University of the Republic

Hippocampal and retrosplenial goal distance coding after long-term consolidation of a real-world environment

Recent research indicates the hippocampus may code the distance to the goal during navigation of newly learned environments. It is unclear however, whether this also pertains to highly familiar environments where extensive systems-level consolidation is thought to have transformed mnemonic representations. Here we recorded fMRI while University College London and imperial College London students navigated virtual simulations of their own familiar campus (> 2 years of exposure) and the other campus learned days before scanning. Posterior hippocampal activity tracked the distance to the goal in the newly learned campus, as well as in familiar environments when the future route contained many turns. By contrast retrosplenial cortex only tracked the distance to the goal in the familiar campus. All of these responses were abolished when participants were guided to their goal by external cues. These results open new avenues of research on navigation and consolidation of spatial information and underscore the notion that the hippocampus continues to play a role in navigation when detailed processing of the environment is needed for navigation

Lengua, comunicación e información

This book, which emerges from the presentations made in the Faculty of Information and Communication in 2017 during two academic meetings: the Colloquium Communication, language and information: reading and writing in academic key and the thematic table Multiple looks for multiple literacies, made in the II Research Days. The written versions of these works are available, which have allowed to start a dialogue about academic reading and writing from three perspectives: communication, information and language sciences. It is hoped that this text will contribute to the dialogue between disciplines not only with the aim of improving the understanding of the same object - writing practices and the processing and communication of information in academic fields - but also contribute to improving teaching, a primary goal of the University of the Republic